ObjectiveTo study the characteristics and risk factors of infections in patients with earthquake injury. MethodsInfections from 140 patients who were injured in Wenchuan earthquake and admitted in a hospital from May 16 to August 20, 2008 were analyzed by prospective study. ResultsThe infection rate of 140 patients was 40.71% (57/140) and nosocomial infection rate was 28.57%(40/140) in patients with earthquake injury. Gramnegative bacilli were  the main pathogens among 88 strains of pathogens in infection, which accounting for 57.09%; 5 strains of anaerobic bacteria were isolated from wound.  Infection had a significant correlation with AISISS score, the higher  AIS-ISS score was, the higher rates of infections were. ConclusionInfection is a common complication of earthquake injury, it is necessary to analyze AISISS score for predicting the occurrence of nosocomial infection, and take effective measures to prevent and control traumatic infection.