ObjectiveTo analyze  clinical characteristics of 40 patients with AIDS in a hospital. MethodsClinical data of 40 HIVinfected patients who were admitted  between January  2003 and August 2004 were analyzed retrospectively. ResultsAll patients were in AIDS stage, CD4+T lymphocytes counts were (156.54±131.26)/μL(normal value were 800~1 200/μL).  The main clinical manifestations included fever, cough and expectoration, loss of weight, abdominal pain, diarrhea and  cervical  lymphadenectasis, some patients developed Kaposi’s sarcoma; The main opportunistic infections and complications  were hepatitis virus infection (30 cases,75.00%), pulmonary tuberculosis (15 cases, 37.50%).  HIV infections were  mainly through intravenous drug injection (32 cases,80.00%), and sex contact (4 cases,10.00%). Patients’ exposure to HIV time (intravenous drug injection, sex contact and blood transfusion) were 2~12 years, the average time were (7.31±1.30) years.ConclusionThe clinical manifestations of AIDS patients are various, and the main infection route is intravenous drug injection, multiple measures should be taken to prevent and control HIV transmission, patients should undergo effective untiviral treatment, monitor and followup, so as to control opportunistic infection and virus replication.