ObjectiveTo evaluate  the detection and antimicrobial susceptibility of imipenemresistant Pseudomonas aeruginosa (IRPA)  isolated from patients with nosocomial infection. MethodsData about IRPA of patients in 110 hospitals in Chinese Nosocomial Infection Surveillance System (CNISS) between July,1999 and June，2007 were analysed. ResultsAmong 5 490 strains of Pseudomonas aeruginosa, 3 090 strains were performed antimicrobial susceptibility test of impenem, 940 strains (30.42%) of which were IRPA. IRPA were mainly distributed in medical university (college)affiliated hospitals and general hospitals with more than 900 beds (847 strains, 90.11%); 2 years were as a stage, the detection rate of IRAP increased significantly with every stage (χ2=27.50, P=0.000); IRAP were mainly from lower respiratory tract, which accounting for 72.13%, the next were burn sites 7.87%. Antimicrobial resistant rate of IRAP to commonly used antimicrobial agents in clinic were >50%, the resistant rate to meropenem was up to 83.33%. ConclusionThe detection of IRAP is high, especially in large general hospitals, there is a tendency of increase and broad drugresistance