ObjectiveTo improve the technical level of making hand lotion to reduce the expense of hospital. MethodsHand lotion were prepared with the multifunction mixer, then the efficacy and skin irritation of selfmade hand  lotion were compared  with the outpurchased  Jiefurou antibacterial hand lotion. ResultsBoth selfmade hand lotion and Jiefurou antibacterial hand lotion meet the standard in the efficacy of washing hand and the skin irritation, there are no significant difference (P>0.05).According to the amount of hand lotion 60 L used daily, 900 yuan can be saved daily, and 300 000 yuan can be saved every year. ConclusionIt is  simple,effective and feasible to prepare and use selfmade hand lotion. It can reduce the cost of hospital and play active role in preventing and controlling nosocomial infection.