ObjectiveTo evaluate the impact of intrahepatic cholestasis of pregnancy (ICP) with HBV infection on prognosis of perinatal infants.MethodsBy retrospective investigation, 78 cases whose mothers with ICP and  HBV infection and 62 cases  whose mothers with ICP but without HBV infection were compared and analyzed, the weight of perinatal infants, incidence of preterm delivery, cesarean delivery, fetal distress, asphyxia of perinatal infants were analysed.  ResultsThe incidence of  preterm delivery whose mothers with ICP and HBV infection was 64.10% (50/78), and whose mothers with ICP but without  HBV  infection was 38.71% (24/62), there was  significant difference between the two groups（χ2＝8.94, P<0.01）,whereas the incidence of cesarean delivery, fetal distress, asphyxia  and  weight of perinatal infants had no statistical difference（All P>0.05）.ConclusionICP with HBV infection can increase the  incidence of  preterm delivery. Monitoring and treatment should be strengthened for HBV infected pregnant women with ICP, so as to ensure the safety and health of perinatal infants.