Objective To investigate the infection with methicillin resistant Staphylococcus (MRS) and isolation rate of heterogeneous vancomycinintermediate Staphylococcus(hVIS) in hospitalized patients .MethodsStaphylococcus strains isolated from samples of infected inpatients were selected, bacteria  were identified and performed antimicrobial susceptibility test by BDphoenix100 microbial autoanalysis system, MRS were detected by cefoxifin disk diffusion method, 41 strains of MRS isolated from aseptic body fluids and secretions were selected for detecting the susceptibility to vancomycin by the broth dilution; The hVIS strains induced on the brain heart infusion (BHI) agar plate were studied by Etest method to investigate their sensitivity to vancomycin.Results There were 160 strains of MRS in 239 isolated Staphylococcus strains. MRS were mainly isolated from patients’ sputum, pus, blood, pleural effusion, and hydrops abdominis . Both methicillin resistant Staphylococcus aureus(MRSA) and coagulasenegative Staphylococcus (CNS) were multidrugresistant, but the sensitive rates to linezolid and furadantin were 100.00%, no highly vancomycinresitant strains  was found. The detection rate of hVIS in  aseptic body fluid and secretion was 14.63%(6/41), the isolation  rate of Staphylococcus aureus and CNS was 7.14%(1/14) and  18.52%(5/27) respectively . Conclusion Accurate detection of MRS and hVIS is  important to control clinical infection efficiently .
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