Objective To analyze the clinical features of patients with infective endocarditis ( IE) , so as to improve its diagnosis and treatment. Methods Clinical data of  182 patients with IE  were analyzed retrospectively. ResultsThe incidence of  underlying heart diseases for IE in  all patients were congenital heart diseases(35.17%),  mitral valve prolapse with mitral insufficiency (24.73%), and rheumatic heart disease(13.19%). The most common clinical manifestations were fever (97.25%) and anemia(88.46%);  Streptococcus sanguis (11.76%) was the most common pathogen in blood culture followed by Staphylococcus aureus (11.03%). 173 (95.05%) cases were detected to have vegetation by the transthoracic echocardiography. Two of 119 patients (1.68%) with surgical operation  and 6 of 63 patients (9.52%) with internal medical treatment died, the primary causes for death were cerebral embolism and acute heart failure. Conclusion The risk factors for IE in recent years are different from those in the past years. The proportion of congenital heart diseases are increasing while that of the rheumatic heart disease is decreasing; Streptococcus spp. and Staphylococcus spp. are major pathogens of IE, the species of pathogens are characterized to be diversified and complex as well. The positive rate of blood culture needs to be improved. Surgical operation in time can improve the prognosis of IE.