ObjectiveTo explore the pathogenic distribution and drug resistance  of  ventilatorassociated pneumonia(VAP) in ICU.MethodsEtiological data of 106 patients who were diagnosed as VAP from January,2006 to January, 2009 in a hospital  were analyzed retrospectively.ResultsA total of 247 pathogens were isolated, 162 ( 65.59%) were gramnegative bacteria, the main bacteria of which were Pseudomonas aeruginosa (55 strains) and Acinetobacter baumannii (34 strains); 35 strains (14.17%) were  grampositive bacteria, the main bacteria of which were Staphylococcus aureus (31 strains),  22（70.97%） of  which were methicillinresistant; 50 (20.24%) fungi strains  were isolated. Drug resistant rates of Pseudomonas aeruginosa to imipenem/cilastatin, tobramycin, piperacillin/tazobactam, and ceftazidime were all<30%; Staphylococcus aureus, especially methicillinresistant Staphylococcus aureus were sensitive to vancomycin and teicoplain, but resistant rates to clindamycin, penicillin, erythromycin and amikacin were all >80%.ConclusionVAP in ICU is mainly induced by gramnegative bacteria, and drug resistance are common.