ObjectiveTo study the  effect of anticommon cold broth on the prevention and remission of  handfootmouth disease(HFMD).MethodsUsing on the spot trial, secondary infection rate and  incidence rate of clinical symptoms were compared between trial group (anticommon cold broth on the basis of standard prevention and control)  and control group (standard prevention and control ) , and  results were analysed with Logistics regression analysis.ResultsThe secondary infection rate in  trial group and control group was 21.90%（23/105）and 51.09%（47/92）respetively, the former was significantly lower than the latter（p＜0.001，OR=0.27，95%CI:0.15～0.50）. Conditional Logistic regression fitted by COX model revealed that the adjusted odds ratio was 0.31（P=0.00，95% CI:0.20～0.48）. There were 17 cases(constitutional ratio:73.91%, 17/23) in trial group and 21 cases(constitutional ratio:44.68%, 21/47) in control group had latent infection , the constitutional ratio of latent infection in trial group was higher than the control group（P=0.02,OR=3.51，95%CI:1.18～10.48）.Logistic regression was used to adjust the contributions of the types of virus, age and gender, the results reveal that the odds ratio of latent infection of the trial group by the control group was 3.17(P=0.01，95% CI: 1.30～9.75）.ConclusionAnticommon cold broth can prevent the secondary infection of HFMD, and relieve its symptoms .