ObjectiveTo analyze the distribution and drug sensitivity of nonfermentative bacteria in lower respiratory tract infection. MethodsSixty hundred and fortyeight cases with nonfermentative bacterial lower respiratory tract infection between January , 2006 and December , 2008 were analysed .ResultsThe first four isolated  nonfermentative bacteria were  Pseudomonas aeruginosa (277 strains, 42.75%), Acinetobacter baumannii (158 strains, 24.38%), Stenotrophomonas maltophilia (59 strains,9.10%) and Burkholderia cepacia (47 strains, 7.25%). Infection cases   mainly distributed in  local officials wards (261 strains, 40.28%) and military cadres wards (120 strains,18.52%) with the older average age of patients,  department of respiratory medicine (111 strains, 17.13%) and intensive care unit (96 strains, 14.81%) also had a higher isolation rates.  Pseudomonas aeruginosa was sensitive to amikacin and imipenem ; Acinetobacter baumannii was sensitive to imipenem, ciprofloxacin, amikacin and antimicrobial agents with βlactamas inhibitors ; Stenotrophomonas maltophilia was strongly resistant to multiple antimicrobial agents ,but sensitive to sulfamethoxazole/trimethoprim only. Burkholderia cepacia had higher drugresistant rate,but was sensitive to piperacillin/tazobactam and cefoperazone/sulbactam.ConclusionNonfermentative bacteria  are important pathogen in  nosocomial lower respiratory tract infection, and most of them are serious drug resistant, drug sensitivity varies with different types of strains, clinical treatment should be based on antimicrobial susceptibility tests  and  mechanisms of drug resistance.