ObjectiveTo study the clinical value of toxin A & B (CDAB) assay in diarrheal inpatients. MethodsFaecal specimens from 47 inpatients with diarrhea were tested by the VIDAS Clostridium difficile (C. difficile) toxin A & B (CDAB) assay, and the results were analyzed together with the bacterial routine culture, clinical data and treatment.ResultsAmong 47 cases of diarrhea patients, 7  (14.89%) were VIDAS CDAB+, the results conformed with clinical diagnosis and/or treatment.ConclusionThe situation of C. difficile infection in this hospital is severe. VIDAS C. difficile Toxin A & B (CDAB) assay is simple, rapid and accurate, which is recommended to be used clinically.