ObjectiveTo study the antimicrobial resistance of extendedspectrum betalactamase(ESBLs)producing bacteria isolated from children, so as to provide reference for treating infections with ESBLsproducing bacteria. MethodsOne hundren ESBLsproducing strains and 100 nonESBLsproducing strains were randomly selected from Children’s Hospital of Shanxi Province between January 2007 and April 2009, and their antimicrobial resistance were campared. ResultsAll 200 strains were sensitive to imipenem; the resistance of ESBLspositive strains to the other 11 kinds of antimicrobial agents were higher than that of ESBLsnegative strains (P≤0.001). Except resistance to cefoperazone/sulbactam was low (13.00%), the resistance of ESBLspositive strains to the other cephalosporins were all>98%; The resistant rate to gentamycin and ciprofloxacin was 69.07% and 59.18% respectively. ConclusionESBLsproducing strains isolated from children are sensitive to carbapenems or antimicrobial compound inhibitors (such as cefoperazone /sulbactam).