某院2006—2008年临床主要病原菌分布及耐药性变迁
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戴锴

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R969.3

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Distribution and change in drug resistance of clinical isolates in a hospital from 2006 to 2008
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    摘要:

    目的分析某院2006—2008年临床主要病原菌的分布及对常用抗菌药物的耐药性变迁。方法常规分离、培养并鉴定细菌,采用纸片扩散法对细菌进行药敏试验。结果共分离病原菌3 499株,其中革兰阳性(G+)菌844株(24.12%),革兰阴性(G-)菌2 655株(75.88%)。耐甲氧西林金黄色葡萄球菌(MRSA)检出率为60.29%(208/345);肠杆菌科细菌对碳青霉烯类抗生素仍然高度敏感,大肠埃希菌和克雷伯菌属中产超广谱β内酰胺酶(ESBLs)株检出率分别为45.23%(403/891)和38.92%(130/334);铜绿假单胞菌对亚胺培南和美罗培南的耐药率较高,分别为41.06%和34.52%,不动杆菌属细菌对亚胺培南和美罗培南的耐药率相对较低,分别为15.52%和31.90%。结论该院临床分离的病原菌中,MRSA与产ESBLs菌检出率较高;加强细菌耐药性监测有助于临床医生合理选择抗菌药物,防止耐药菌株的流行与传播。

    Abstract:

    ObjectiveTo investigate the distribution and change in drug resistance of clinical isolates in a hospital from 2006 to 2008.MethodsBacteria were isolated and identified by routine methods, antimicrobial susceptibility test was carried out by KirbyBauer method.ResultsA total of 3 499 clinical isolates were collected, grampositive and negative bacteria accounted for 24.12% (844 strains) and 75.88% (2 655 strains) respectively. 60.29% (208/345) of Staphylococcus aureus isolates were identified as methicillinresistant Staphylococcus aureus. Isolates of Enterobaceriaceae were still highly sensitive to carbapenem antibiotics. ESBLsproducing strains accounted for 45.23%(403/891) in Escherichia coli and 38.92% (130/334) in Klebsiella spp. respectively; Pseudomonas aeruginosa isolates showed relatively higher resistant rates to imipenem and meropenem,  which was 41.06% and 34.52% respectively, Acinetobacter spp. isolates showed relatively lower resistant rates to imipenem and meropenem, which was 15.52% and 31.90% respectively.ConclusionThe prevalence of MRSA and ESBLsproducing strains is high; surveillance of antimicrobial resistance can help clinicians use antimicrobial agents rationally and control the transmission of drugresistant strains.

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戴锴,杨丽华,龚作炯.某院2006—2008年临床主要病原菌分布及耐药性变迁[J]. 中国感染控制杂志,2010,9(5):346-350.
DAI Kai, YANG Lihua, GONG Zuojiong. Distribution and change in drug resistance of clinical isolates in a hospital from 2006 to 2008[J]. Chin J Infect Control, 2010,9(5):346-350.

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  • 收稿日期:2010-04-08
  • 最后修改日期:2010-06-13
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  • 在线发布日期: 2010-09-30
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