ObjectiveTo investigate the characteristics of the distribution and drugresistance of Acinetobacter spp. in a cardiovascular special hospital.MethodsThe distribution and drugresistant rates of Acinetobacter spp. which isolated from clinical specimens from January,2006 to December,2009 were analysed retrospectively.Results409 Acinetobacter spp. were mainly isolated from sputum(75.79%),followed by blood(8.56%), the rest from others(urine,venous catheter,secretions) and accounted for 15.65%; department distribution : Acinetobacter spp. were mainly isolated from surgical ICU and accounted for 40.59%,followed by medical ICU and accounted for 37.41%,other departments(including surgery and internal medicine) was 22.00%;bacteria distribution: Acinetobacter spp. consisted of Acinetobacter baumannii(80.20%),followed by Acinetobacter lwoffii(16.87%)and Acinetobacter haemolyticus(2.93%). Acinetobacter spp. had low drugresistant rates to cefoperazone/sulbactam, piperacillin/tazobactam, ceftazidime,cefepime,gentamycin,amikacin and ciprofloxacin, drugresistant rate was 2.69%,14.18%,19.56%,15.16%,15.65%, 9.29%,and 14.18%, respectively. The percentage of drugresistant rate to imipenem and meropenem was 3.67% and 5.87% respectively, while it was over 57% to the other antimicrobial agents .ConclusionAcinetobacter spp. is one of nonfermentative bacteria in nosocomial infection, the main infection is respiratory tract infection , and shows serious drugresistance. Cefoperazone/sulbactam and carbapenems are effective antibiotics for treating infections caused by Acinetobacter spp..