ObjectiveTo explore the method to improve hygienic hand disinfection compliance among healthcare workers.MethodsA series of measures were drawn up by applying total quality management (TQM) theory and method to improve hygienic hand disinfection compliance among healthcare workers, investigated data of June,2008 was as basic information, 2009-2010 was intervention enforcement stage, and data was summarized in 2010 .ResultsThree investigations between June,2008 to June,2010 were carried out, the hygienic hand disinfection compliance rate rose from 35.23% (315/894) in 2008 to 53.11%(563/1 060) in 2010, there was significant difference between the two (χ2＝62.65，P＜0.01).ConclusionTQM can enhance effectively the compliance to hygienic hand disinfection among healthcare workers.