ObjectiveTo study the related factors and appropriate strategies for infections in patients with type 2 diabetes mellitus (DM)，so as to reduce nosocomial infection(NI) rate.MethodsFortyeight type 2 DM patients with NI （NI group）and 55 type 2 DM patients without NI (control group) during the same hospitalization period were selected , patients’ age at admission , fasting blood sugar, glycohemoglobin, hospital stay, immunization level, invasive procedure , antimicrobial use , and continuous subcutaneous insulin infusion in two groups were compared .ResultsPatients’ average age at admission (［62.57±14.35］ years old), fasting blood sugar(［10.26±3.68］mmol/L), glycohemoglobin(［8.38±2.95］%), and hospital stay(［21.38±10.77］days) in NI group were higher than (［44.40±12.82］ years old), (［8.96±2.92］ mmol/L), (［6.73±2.57］%) ,and (［16.24±9.62］days) respectively in  control group,there was significant difference between two groups(all P<0.05);Immunization levels in two groups were not statistically significant(P>0.05); invasive  procedure rate in NI group (16.67%) and ≥2 typies of antimicrobial usage rate (68.75%) in NI group  were both higher than those (3.64%,9.09%) of control group  respectively, continuous subcutaneous insulin infusion rate  in control group(67.27%) was higher than that of NI group(14.58%), the difference was significant(P<0.05).ConclusionMultiple factors can influence the occurrence of NI in type 2 DM patients, surveillance should be intensified , comprehensive strategies should be taken to prevent the occurrence of NI.