ObjectiveTo study the express and clinical significance of serum interleukin18 （IL18）, vascular endothelial growth factor （VEGF） and transforming growth factor β1 (TGFβ1) in HBV/HCV/HIV coinfection patients .MethodsSerum IL18, VEGF and TGFβ1 levels in patients with HBV/HCV/HIV coinfection or simple HBV or HCV infection were detected with ELISA method，and liver function biochemical indicators of alanine transaminase(ALT), aspartate aminotransferase(AST),gamma glutamyl transferase（GGT） levels were simultaneously detected , correlation between these indicators and IL18,VEGF, TGFβ1 was analyzed ; 30 healthy people were randomly selected as control group ,statistical analysis was made.ResultsSerum IL18, VEGF, and TGFβ1 values in patients with HBV/HCV/HIV coinfection were not associated with gender (P>0.05), which were significantly higher than that of simple HBV or HCV infection and normal control group (P<0.01)，and was the highest in patients with HBV+HCV+HIV coinfection (IL18,VEGF,TGFβ1 levels were ［312.44±45.24］pg/L，［326.43±51.24］pg/mL and ［283.51±49.27］μg/L， respectively) ，followed by HCV+ HIV coinfection，which were （［224.32±34.37］pg/L，［257.72±47.72］pg/mL and ［204.11±43.28］μg/L， respectively), HBV+ HIV coinfection were （［129.44±27.62］pg/L，［147.67±41.22］pg/mL and ［120.47±30.23］μg/L respectively). In patients with HBV/HCV/HIV coinfection ,serum IL18,VEGF, and TGFβ1 levels were positively correlated with ALT,AST, and GGT (r value was 0.667, 0.652, 0.672； 0.643, 0.618. 0.623; 0.712, 0.673 and 0.705， respectively).ConclusionDetection of serum IL18,VEGF,and TGFβ1 levels are important to evaluate the status of patients with HBV/HCV/HIV coinfection .