ObjectiveTo explore the treatment strategy for entecavirrefractory chronic hepatitis B (CHB) patients.MethodsOne entecavirrefractory CHB patient was switched to combination treatment of lamivudine with adefovir dipivoxil, and levels of HBV DNA and serum alanine transaminase (ALT) were followed up.ResultsAfter one year combined treatment , patient’s serum HBV DNA level dropped to 1.19×103IU/mL from the initial top of 2.02×108IU/mL and ALT level was recovered to normal range (≤40 U/L). ConclusionThe combination use of lamivudine with adefovir dipivoxil is effective for this entecavirrefractory CHB patient , but whether the treatment can be popularized needs to be further investigated.