呼吸道苛养菌对头孢妥仑匹酯等10种抗菌药物的药敏监测
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袁锦屏

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R969.3

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Susceptibility of cefditoren pivoxil and other nine antimicrobial agents against fastidious bacteria isolated from respiratory tract
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    摘要:

    目的了解呼吸道感染苛养菌的分离及其对头孢妥仑匹酯等10种抗菌药物的药敏情况,为临床治疗提供参考。方法收集2005年、2007年、2008年及2010年1—6月从呼吸道细菌感染患者送检的痰标本中分离的苛养菌,采用美国临床实验室标准化研究所推荐的KB法检测头孢妥仑匹酯等10种抗菌药物对其的体外抗菌活性。结果438例患者共分离苛养菌462株,其产β内酰胺酶率:流感嗜血杆菌23.62%(30/127),副流感嗜血杆菌2.51%(5/199),卡他莫拉菌41.58%(42/101),未发现对青霉素中介或耐药的肺炎链球菌。流感嗜血杆菌、副流感嗜血杆菌、卡他莫拉菌及肺炎链球菌对头孢妥仑匹酯的敏感率分别为96.30%、94.36%、100.00%、100.00%;流感嗜血杆菌和副流感嗜血杆菌对头孢噻肟、头孢呋辛、头孢克罗、头孢唑林的敏感率为83.59%~93.33%,对阿莫西林/克拉维酸的敏感率分别为91.67%、88.21%;卡他莫拉菌、肺炎链球菌对阿莫西林/克拉维酸的敏感率为100.00%;对克拉霉素的敏感率,流感嗜血杆菌为87.96%,其他3种菌为34.29%~59.00%;4种苛养菌对四环素的敏感率较低,为22.86%~63.00%;流感嗜血杆菌、副流感嗜血杆菌、卡他莫拉菌对复方磺胺甲口恶唑的耐药率高,达54.63%~73.33%。结论头孢妥仑匹酯对呼吸道感染的苛养菌具有很强的抗菌活性;临床医生应根据药敏试验结果合理使用抗菌药物,以减少耐药菌的产生。

    Abstract:

    ObjectiveTo realize the isolation status of fastidious bacteria causing respiratory tract infection and antimicrobial susceptibility of fastidious bacteria to cefditoren pivoxil as well as the other 9 antimicrobial agents, so as to provide reference for clinical treatment.Methods Fastidious bacteria isolated from sputum of patients with respiratory tract infection during the year of 2005, 2007, 2008, and JanuaryJune in 2010 were collected. Antimicrobial susceptibility of fastidious bacteria were tested with KirbyBauer method recommended by Clinical and Laboratory Standards Institute (CLSI). ResultsA total of 462 isolates were isolated from 438 patients, βlactamaseproducing rate was as follows: Haemophilus influenzae (HI) 23.62% (30/127), Haemophilus parainfluenzae (HP) 2.51%(5/199), Moraxella catarrhalis (MC) 41.58% (42/101), penicillinresistant Streptococcus pneumoniae (SP) isolates was not found. The susceptibility rate (SR) of HI, HP, MC, and SP to cefditoren pivoxil was 96.30%, 94.36%, 100.00%, and 100.00%, respectively;The SR of HI and HP to cefotaxime, cefuroxime, cefaclor and cefazolin was 83.59%-93.33%, SR to amoxicillin/clavulanic acid was 91.67% and 88.21% respectively; SR of MC and SP to amoxicillin / clavulanic acid was 100.00%; SR of HI to clarithromycin was 87.96%,SR of HP, SP and MC to clarithromycin was 34.29%-59.00%; SR of 4 kinds of fastidious bacteria to tetracycline was 22.86%-63.00%; The resistant rate of HI,HP and MC to trimethoprim/sulfamethoxazole was 54.63%-3.33%.ConclusionCefditoren pivoxil has strong activity against fastidious bacteria causing respiratory tract infection; in order to reduce the emergence of drugresistant strain, clinicians should choose antimicrobial agents according to antimicrobial susceptibility test results.

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袁锦屏,杨灵,邱桂霞,等.呼吸道苛养菌对头孢妥仑匹酯等10种抗菌药物的药敏监测[J]. 中国感染控制杂志,2011,10(4):289-291.
YUAN Jinping, YANG Ling, QIU Guixia, et al. Susceptibility of cefditoren pivoxil and other nine antimicrobial agents against fastidious bacteria isolated from respiratory tract[J]. Chin J Infect Control, 2011,10(4):289-291.

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  • 收稿日期:2010-10-29
  • 最后修改日期:2010-12-22
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  • 在线发布日期: 2011-07-30
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