致呼吸机相关性肺炎的鲍曼不动杆菌分子分型
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庞杏林

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R563.1

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广州市医药卫生科技项目(2006YB131)


Genotyping of Acinetobacter baumannii causing ventilatorassociated pneumonia
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    摘要:

    目的了解引起呼吸机相关性肺炎(VAP)的鲍曼不动杆菌(Ab)分子流行病学特征。方法对分离自VAP患者下呼吸道分泌物标本中的7株Ab菌株进行脉冲场凝胶电泳(PFGE)分型及耐药性检测。结果7株Ab的PFGE电泳条带相似度为57%~100%, 分为A、B、C、D 4个PFGE型别,其中A、B、D型各2株(28.57%),C型1株(14.29%)。Ab对头孢他啶、亚胺培南和妥布霉素等13种抗菌药物产生不同程度的耐药性,均为泛耐药菌株,其中C型Ab为全耐药菌株。结论PFGE分型技术可以准确和快速地用于Ab引起的医院感染溯源、分型。

    Abstract:

    ObjectiveTo evaluate the molecular epidemiological features of Acinetobacter baumannii (Ab) causing ventilatorassociated pneumonia(VAP).MethodsSeven strains of Ab isolated from lower respiratory tract secretion of VAP patients were typied by pulsedfield gel electrophoresis (PFGE), and drugresistance of strains were detected.ResultsThe similarity of PFGE electrophoresis strips of 7 strains was 57%-100%, there were 4 PFGE patterns(A,B,C and D), 2(28.57%) strains were for pattern A, B and D respectively, 1(14.29 %) strain was for pattern C. Ab had different drugresistance to 13 kinds of antimicrobial agents (ceftazidime, imipenem,tobramycin, etc.), all were pandrugresistant strains, pattern C strain was alldrugresistant strain.ConclusionPFGE typing can accurately and quickly trace the homology of nosocomial infection caused by Ab.

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庞杏林,张颖,胡玉山,等.致呼吸机相关性肺炎的鲍曼不动杆菌分子分型[J]. 中国感染控制杂志,2011,10(5):337-340.
PANG Xinglin, ZHANG Ying, HU Yushan, et al. Genotyping of Acinetobacter baumannii causing ventilatorassociated pneumonia[J]. Chin J Infect Control, 2011,10(5):337-340.

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  • 收稿日期:2011-03-03
  • 最后修改日期:2011-05-12
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  • 在线发布日期: 2011-09-30
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