ObjectiveTo evaluate the risk factors for nosocomial Staphylococcus haemolyticus (S. haemolyticus) infections (NIs) in intensive care units (ICUs) . MethodsA 1∶4 matched casecontrol study was carried out on ICU patients (28 cases) with S. haemolyticus NIs in an integrated hospital between 2007-2009. Conditional logistic regression analysis was adopted.ResultsUnivariate conditional logistic regression analysis showed that S. haemolyticus NIs were related with the number of underlying diseases，days of ICUs stay，adjusted days of ICUs stay， days of antimicrobial use， combination use of antimicrobials ，use of broadspectrum antimicrobials ，turning over and back patting，sputum aspiration，trachea intubation，use of ventilator，retention of nasogastric tube and central venous catheter. Multivariate logistic regression analysis showed that retention of nasogastric tube（OR=4.89） and ventilator（OR=5.32） were risk factors, and turning over and back patting（OR=0.21）were protective factors.ConclusionSound and effective practice of turning over and back patting ，use of noninvasive ventilation and reducing invasive procedures are helpful for the control and prevention of S. haemolyticus NIs.