ObjectiveTo analyze risk factors for surgical site infection（SSI） in digestive tract surgery.MethodsTargeted monitoring data of SSI in a hospital between January 2009 to December 2010 were analyzed retrospectively, univariate and multivariate analysis were conducted on 20 suspected risk factors, including types of diseases(surgical sites), operation season,gender, age,types of surgery,modes of anaesthesia, wound class, blood transfusion, ASA score, risk index, operation time, underlying diseases, invasive operation, and perioperative use of antimicrobial agents.ResultsSSI in digestive tract surgery was closely related with multiple factors, such as surgical sites, gender, types of surgery, wound class, blood transfusion, ASA score and risk index(all P<0.05), among which gender and risk index were 2 independent risk factors.ConclusionMultiple factors contribute to SSI in digestive tract surgery, and comprehensive preventive measures should be taken to reduce SSI rate.