ObjectiveTo survey the data of healthcareassociated methicillinresistant Staphylococcus aureus (HAMRSA) infection in a hospital, and evaluate the impact of the reinforcement of infection control.MethodsA series of comprehensive infection control measures were undertaken, the incidence of HAMRSA infection /1 000 patientdays and the amount of hand hygiene product consumption/patient day from 2008 to 2010 were analyzed and compared. ResultsThe incidence of HAMRSA infection/1 000 patientdays in this  hospital was 0.41‰, 0.30‰, and 0.27‰ in 2008, 2009 and 2010 respectively (χ2=18.918,P=0.000); the amount of hand hygiene product consumption / patientday  increased each year (11.36-27.41 mL/patient  day) (F=0.108, P=0.750);there was no significant correlation between incidence of HAMRSA infection/1 000 patientdays and the amount of hand hygiene product consumption/patientday (F=0.022,P=0.886).The incidence of HAMRSA infection/1 000 patientdays in intensive care unit was 2.13 ‰, 1.99‰  and 2.20‰ in 2008, 2009, and 2010 respectively.ConclusionThe decreasing trend of the incidence of HAMRSA infection/1 000 patientdays (χ2=0.178,P=0.915) emphasizes the effectiveness of the reinforcement of comprehensive  infection control programme.