ObjectiveTo investigate the DNA homology of MRSA isolated from patients in a surgical intensive care unit (SICU) and SICU environment, so as to provide reference for the control of MRSA spread in hospital.MethodsMRSA were isolated from SICU patients and environment from August to October 2010． RepPCR based DiversiLab microbial typing system was applied to analyze the homology of MRSA．ResultsOf 124 samples, 12 MRSA were isolated, with 9 of 10 MRSA isolates from patients and 3 MRSA isolates from environment. They were highly homologous.ConclusionMRSA isolated from SICU patients are highly homologous to those from SICU environment. MRSA transmission in this SICU is serious.