ObjectiveTo realize the characteristics and drug resistance of communityassociated(CA) and healthcareassociated(HA) methicillinresistant Staphylococcus aureus(MRSA) infection, and provide reference for the prevention and control of MRSA infection.MethodsData of MRSAinfected patients who were hospitalized between January and June 2010 were reviewed and analyzed retrospectively. ResultsThe major CAMRSA infection site was skin and soft tissue (58.82%). The rate of CAMRSA respiratory tract infection and HAMRSA respiratory tract infection was 29.41% and 29.63% respectively. There was significant difference in age, length of hospital stay, ICU stay, surgical operation and invasive operation between CAMRSA and HAMRSA infected patients(P<0.05). The resistant rate of HAMRSA to rifampicin, gentamicin,moxifloxacin, and ciprofloxacin were all higher than those of CAMRSA (74.19%-93.33% vs 37.50%-52.94%, P<0.05).ConclusionCAMRSA infection varies from HAMRSA infection in infection characteristics and drug resistance, prevention and control measures should be strengthened, and antimicrobial agents should be used according to antimicrobial susceptibility testing result.