ObjectiveTo evaluate the epidemiology, clinical features, treatment and prognosis of Penicilliosis marneffei (PSM) complicated in patients with acquired immunodeficiency syndrome (AIDS) in a hospital.MethodsClinical data of AIDS inpatients with PSM between January 2008 and August 2011 were studied retrospectively.ResultsClinical data of 33 patients were collected. Before the onset of disease, 54.55% of the patients had been living in Hunan, 45.45% came from or have ever been to Penicillium marneffei (PM) endemic areas of Guangdong, Guangxi, Yunnan, and Fujian. The major clinical manifestations were fever (96.97%), anaemia (93.94%), cough (66.67%), splenomegaly (63.64%), skin rash (57.58%), lymphadenectasis (39.39%) and diarrhea(33.33%). CD4+T lymphocyte count of all patients were <200/mm3, and the number of the patients with CD4+ count in 100-200/mm3，50-100/mm3 and <50/mm3 ranges were 1,7 and 25, respectively. After treated with amphotericin B and/or itraconazole,the total cure and improvement rate was 84.85%.ConclusionWith regard to PSM complicated in AIDS patients, early diagnosis and prompt treatment can achieve ideal therapeutic effet.