ObjectiveTo evaluate risk factors for surgical site infections (SSIs) after appendectomy, and provide reference for developing infection control strategies. MethodsData of 512 patients who received appendectomy between August 2010 and December 2011 were reviewed and analyzed.ResultsFortytwo of 512 patients developed SSIs, infection rate was 8.20%, all were superficial incisional SSIs. Univariate analysis showed that SSIsrelated factors were patients’ age, subcutaneous tissue thickness, diabetes, types of anesthesia, duration of surgery, season of surgery, types of incision, pathology of appendix (all P<0.05). Multivariate Logistic regression analysis showed that the risk factors for SSIs were types of incision(OR 95%CI, 2.75-67.45), subcutaneous tissue thickness(OR 95%CI, 4.54-45.81), diabetes(OR 95%CI, 5.13-29.91), types of anesthesia(OR 95%CI, 1.79-53.28), duration of surgery(OR 95%CI, 8.10-78.63), and pathology of appendix (OR 95%CI:5.51-54.74) (all P<0.05).ConclusionInfection of SSIs should be intensified according to risk factors, so as to prevent the occurrence of SSIs after appendectomy.