ObjectiveTo compare disinfectant efficacy of different disinfectants on the skin of blood donors before donation.MethodsFrom May 2008 to April 2011, 240 volunteer blood donors were divided into 3 groups according to the different skin disinfectants used : iodine tincture and alcohol group, iodophor group, and Anerdian group, there were 80 donors in each group. Samples were taken respectively  before and after skin was disinfected , and disinfectant efficacy as well as disinfectant drying time were  compared.ResultsThe total number of bacteria on the skin was not significantly different among three groups before and after disinfection respectively （all P＞0.05）, after disinfection, bacteria number on the skin of iodine tincture and alcohol group, iodophor group, and Anerdian group were  （0.74±0.36）CFU/cm2  ,（0.82±0.38）CFU/cm2 and （0.65±0.31）CFU/cm2  respectively；the qualified  rates of disinfection were all 100%; disinfectant drying time of three group  were （76.23±5.31）seconds, （104.64±6.82）seconds and（20.41±3.53）seconds,  respectively（F=5.703，P＜0.05）, Anerdian group was  remarkably shorter  than  the other two groups.ConclusionAnerdian disinfectant is suitable for skin disinfection of blood donors before donation，disinfectant efficacy is ideal and disinfectant drying time is short.