ObjectiveTo investigate the prevalence rates of healthcareassociated infection(HAI) and communityassociated infection(CAI) in 19 secondary general hospitals in Handan.MethodsHAI and CAI prevalence rates of inpatients in 19 hospitals were investigated by means of medical record checking and bedside visiting.ResultsA total of 4 897 patients should be surveyed, 4 879 (99.63%) were actually surveyed. Of 4 879 investigated patients, 174 had HAI, and the prevalence rate was 3.57%，1 113 developed CAI,the prevalence rate of CAI was 22.81%; Pediatric department had the highest prevalence rates of HAI (5.16%) and CAI(71.56%);The main infection sites of HAI were lower respiratory tract (36.65%), upper respiratory tract (30.89%) and urinary tract (9.42%); the main infection sites of CAI were lower respiratory tract (40.99%), upper respiratory tract (22.17%) and gastrointestinal tract (5.30%). Antimicrobial usage rate was 60.05%. In patients used antimicrobial agents, 43.92% received curative use, 39.97% received prophylactic use, 16.11% received both. Single antimicrobial use accounted for 68.02%, twodrug 29.56%, threedrug 2.15%, and fourdrug and above 0.27%.ConclusionSurveillance of prevalence rate helps to know the current state and antimicrobial use of HAI and CAI, and make proper prevention and control measures.