糖尿病与非糖尿病患者社区获得性肺炎临床特点与病原学
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方琦

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R587.1R563.1

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Clinical characteristics and etiology of communityacquired pneumonia in diabetic and nondiabetic patients
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    摘要:

    目的分析糖尿病与非糖尿病患者合并社区获得性肺炎的临床特点。方法选取2008年1月—2011年5月在某院住院的社区获得性肺炎患者100例,其中糖尿病患者50例(A组),非糖尿病患者50例(B组),对其病历资料进行回顾性分析。结果A组病程常迁延,平均住院时间为(18.52±4.32)d,较B组(12.64±4.18)d长,两组差异有统计学意义(χ2=6.92,P<0.01);A组患者肝功能多受损:血清丙氨酸转氨酶(ALT)为(52.26±15.18)U/L、天门冬氨酸转氨酶(AST)为(48.44±10.25) U/L,显著高于B组的ALT、AST[分别为(40.39±15.42)U/L、(35.70±9.98)U/L](P<0.05);A组患者肾功能减退,血尿素氮(BUN)和血清肌酐(SCr)分别为(8.02±2.12)mmol/L、(128.05±21.25)μmol/L,显著高于B组的BUN和SCr[分别为(5.35±1.99) mmol/L、(98.20±20.93)μmol/L](P<0.05)。A组混合感染发生率为26.00%,显著高于B组的10.00%;代谢综合征和大血管并发症发生率分别为28.00%、36.00%,明显高于B组的12.00%、10.00%,差异均有统计学意义(均P<0.05)。A组发展为重症肺炎的比率和病死率分别为12.00%(6例)、6.00%(3例),B组分别为4.00%(2例)、2.00%(1例)。A组痰培养阳性41例(82.00%, 41/50),B组痰培养阳性44例(88.00%,44/50),两组检出病原体均以肺炎链球菌(A组16株,B组17株)、肺炎克雷伯菌(A组4株,B组5株)较多。结论糖尿病合并社区获得性肺炎病程长,病情重,合并症多;控制血糖是治疗的基础,抗感染是关键,改善营养和器官功能状态是重要的环节。

    Abstract:

    ObjectiveTo analyze clinical characteristics of communityacquired pneumonia (CAP)in diabetic and nondiabetic patients.MethodsFrom January 2008 to May 2011,100 CAP patients in a hospital were selected, 50 of whom had diabetes (group A) and 50 without diabetes (group B), their clinical data were analyzed.ResultsThe average length of hospital stay in group A was significantly longer than that of group B ([18.52±4.32] d vs [12.64±4.18] d, χ2=6.92,P<0.01); serum alanine aminotransferase (ALT) and aspartate transaminase (AST)in group A were significantly higher than group B ([52.26±15.18] U/L vs [40.39±15.42] U/L; [48.44 ±10.25] U/L vs [35.70±9.98] U/L, P<0.05, respectively); blood urea nitrogen (BUN) and serum creatinine (SCr) in group A were significantly higher than group B ([8.02±2.12] mmol/L vs [5.35±1.99] mmol/L; [128.05±21.25] μmol/L vs [98.20±20.93) μmol/L, P <0.05, respectively). Mixed infection rate in group A was significantly higher than group B (26.00% vs 10.00%); metabolic syndrome and incidence of macrovascular complications were significantly higher than group B (28.00% vs 12.00%; 36.00% vs 10.00%, P<0.05, respectively). Rate of severe pneumonia and mortality in group A was 12.00% (6 cases) and 6.00% (3 cases) respectively,and group B was 4.00% (2 cases) and 2.00% (1 case) respectively, sputum culture positive rate in group A and B was 82.00% (41/50) and 88.00% (44/50) respectively, Streptococcus pneumoniae (16 isolates in group A and 17 in group B) and Klebsiella pneumoniae (4 isolates in group A and 5 in group B)were common in both groups.ConclusionDiabetic patients with CAP have long disease course, with severe illness and multiple complications, controlling blood glucose is the basis of treatment, antiinfection is the key, and improving nutritional state and organ function is important aspect.

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方琦,方铭喜, 姚蔚,等.糖尿病与非糖尿病患者社区获得性肺炎临床特点与病原学[J]. 中国感染控制杂志,2013,12(3):202-204. DOI:10.3969/j. issn.1671-9638.2013.
FANG Qi, FANG Mingxi, YAO Wei, et al. Clinical characteristics and etiology of communityacquired pneumonia in diabetic and nondiabetic patients[J]. Chin J Infect Control, 2013,12(3):202-204. DOI:10.3969/j. issn.1671-9638.2013.

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  • 收稿日期:2012-06-12
  • 最后修改日期:2012-09-22
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  • 在线发布日期: 2013-05-30
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