2009-2011年AIDS住院患者多重耐药菌感染调查及耐药性分析
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邓昕

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R512.91

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Multidrugresistance bacterial infection and antimicrobial resistance in AIDS inpatients during 2009-2011
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    摘要:

    目的了解某院获得性免疫缺陷综合征(AIDS)住院患者的多重耐药菌分布特点及耐药情况,为临床治疗提供依据。方法对2009—2011年住院的AIDS患者各类标本分离的426株多重耐药菌药敏试验结果,应用WHONET5.4软件进行统计分析。结果分离的多重耐药菌包括产超广谱β内酰胺酶(ESBLs)肠杆菌科细菌213株,耐甲氧西林金黄色葡萄球菌(MRSA)41株,耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)21株,多重耐药鲍曼不动杆菌(MDRAB)79株和多重耐药铜绿假单胞菌(MDRPA)72株。检出的产ESBLs肠杆菌科细菌除对少数广谱抗菌药物比较敏感外,对大部分抗菌药物存在不同程度的耐药(耐药率3.74%~100%)。结论住院AIDS患者分离的多重耐药菌以肠杆菌科细菌多见,耐药率高,临床医生应谨慎选用抗菌药物进行经验治疗;同时应加强监测,避免多重耐药菌感染在医院暴发流行。

    Abstract:

    ObjectiveTo study the distribution and drugresistance of multidrugresistant bacteria(MDRB) from inpatients with acquired immunodeficiency syndrome (AIDS), so as to provide reference for clinical therapy.MethodsAntimicrobial susceptibility testing result of 426 MDRB isolates from AIDS inpatients during 2009-2011 was analyzed by WHONET 5.4 software.ResultsThe isolated MDRB included 213 isolates of extendedspectrum βlactamaseproducing Enterobacteriaceae bacteria, 41 methicillinresistant Staphylococcus aureus (MRSA), 21 methicillinresistant coagulase negative Staphylococcus (MRCNS), 79 MDRAcinetobacter baumannii (MDRAB), and 72 MDRPseudomonas aeruginosa (MDRPA). Except lower drugresistance rate to a minority of broad spectrum antimicrobial agents, ESBLproducing Enterobacteriaceae bacteriaca had higher resistance rates (3.74%-100%) to other antimicrobial agents.ConclusionThe major MDRB from AIDS inpatients is Enterobacteriaceae bacteria, clinicians should choose antimicrobial agents for empirical treatment, surveillance should be intensified, so as to avoid the outbreak of MDR infection in hospital.

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邓昕,夏玉朝.2009-2011年AIDS住院患者多重耐药菌感染调查及耐药性分析[J]. 中国感染控制杂志,2013,12(4):256-258. DOI:10.3969/j. issn.1671-9638.2013.
DENG Xin, XIA Yuchao. Multidrugresistance bacterial infection and antimicrobial resistance in AIDS inpatients during 2009-2011[J]. Chin J Infect Control, 2013,12(4):256-258. DOI:10.3969/j. issn.1671-9638.2013.

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  • 收稿日期:2012-10-09
  • 最后修改日期:2012-02-12
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  • 在线发布日期: 2013-07-30
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