ObjectiveTo evaluate the efficacy of different dosage regimen of cefuroxime for preventing surgical site infection(SSI) following laparoscopic cholecystectomy.MethodsA retrospective study was performed by collecting and comparing the data of patients who received laparoscopic cholecystectomy between June 2011 and May 2012. Sixtyeight patients in group A were given 1.5g cefuroxime intravenous drip before operation, and 61 patients in group B were sequentially given another 1.5g cefuroxime postoperatively, SSI in both groups were compared.ResultsSSI in group A and B were 3(4.41%) and 2(3.28%) cases respectively, there was no statistical difference in SSI between two groups（P>0.05）.ConclusionPreoperative prophylactic use of 1.5g cefuroxime can prevent SSI effectively for patients undergoing elective laparoscopic cholecystectomy.