ObjectiveTo evaluate the effect of external fixation of balloon urethral catheter on preventing urinary tract infection in male patients. MethodsTwo hundred tumor male patients were randomly divided into observation group (100 cases) and control group (100 cases). Control group only applied balloon catheter to perform fixation of catheter inside bladder after the success of catheterization; observation group applied the external fixation of balloon catheter on the basis of inner fixation of catheter, urinary tract infection (UTI) on the 3rd, 5th and 7th day of catheterization in two groups of patients were observed and compared. ResultsOn day 3,5,and 7 in observation group, asymptomatic bacteriuria rate was 1.00%，4.00%，and 9.00% respectively, UTI rate was 0.00%，2.00%，and 3.00% respectively;in control group, asymptomatic bacteriuria rate was 7.00%, 13.00%, and 21.00% respectively, UTI rate was 3.00%，7.00%，and 13.00% respectively, asymptomatic bacteriuria rate and UTI in observation group was lower than control group respectively（P＜0.01）. ConclusionApplication of external fixation of balloon catheter for male patients with catheterization can avoid the moving of catheter, and reduce the occurrence of UTI.