ObjectiveTo evaluate the effect of fast detection on occupational blood exposure with unidentified bloodborne infection status. MethodsData of 45 cases of occupational blood exposure with unidentified bloodborne infection status between January and December 2011 were analyzed retrospectively.ResultsBefore fast detection,10(22.22%) source patients were with identified infection status,3(6.67%) exposed healthcare workers (HCWs)were with positive HBsAb; after fast detection,35 (77.78%) source patients were identified the infection status, the identified rate increased by 55.56%,23 HCWs were detected positive HBsAb, 22 HCWs needn’t to be detected, the identified rate was 51.11%, the identified rate increased by 44.44%. Postexposure preventive measures were taken, and no HCWs was found to be infected due to the occupational exposure.ConclusionPostexposure preventive measures according to the result of fast detection can effectively reduce the occurrence of infection due to occupational blood exposure.