ObjectiveTo realize the contamination of reusable dialyzer housing and efficacy of two different disinfection methods on dialyzer housing.Methods300 pieces of used dialyzers were cleaned, checked and disinfected by automatic disinfection machine, then divided evenly into three groups before stored in the cabinet, and specimens were taken from dialyzer housings without being disinfected, wiped with disinfectant containing 500mg/L available chlorine,and immersed with the same disinfectant, respectively.ResultsThe average colony count of dialyzer housings of three groups was as follows: nondisinfection group was （15.52±3.81）CFU/cm2,qualified rate was 87%； wiping disinfection group was （3.22±0.71） CFU/cm2，qualified rate was 100%； qualified rate of immersing disinfection group (immersion time was 10 minutes) was 100%,qualified rate between two disinfection groups and nondisinfection group was different statistically（χ2=7.89，P＜0.05）.ConclusionWiping and 10minute immersion of dialyzer housings with disinfectant containing 500 mg/L available chlorine can both achieve disinfection efficacy, but the latter is better.