ObjectiveTo study epidemiological characteristics of sexually transmitted diseases(STDs) in Zhuhai, and provide a scientific basis for the formulating of STD prevention and control measures.MethodsThe epidemic reporting data (2005—2012) of four zones(towns) in seven administrative districts of Zhuhai were analyzed by stratified cluster sampling method.ResultsIn 2005-2012, 3 566 STD cases were reported, the average annual incidence rate was 116.64/100,000. The occurrence of STDs increased year by year, the average annual incidence per 100,000 population was 14.63,19.64,16.89,78.03,56.91,160.27,232.99, and 245.63, respectively. The incidence of syphilis, acquired immunodeficiency syndrome, gonorrhea, genital herpes, Chlamydia trachomatis genital infection and pointed condyloma was 15.90, 2.00, 17.83, 16.58, 37.09, and 27.25 per 100,000 population, respectively. Reported cases mainly concentrated on population aged 20-39 years (80%). The incidence of syphilis in population aged ＞60 years was higher than those aged 20-39 years (25.92/100,000 vs 19.06/100,000）; the incidence of pointed condyloma in 15-19 age group was higher than the average annual incidence （32.82/100,000 vs 27.25/100,000）; there was an increased trend in the development of STDs in housework and unemployed persons.ConclusionIncidence of STDs tends to increase in this city, there is a greater increase in certain STDs, and there is a growing trend in the incidence among general population, indicating the prevention effort on STDs should go deep into all kinds of people, especially in communities and schools.