(CRP) for detecting healthcareassociated infection(HAI) in hospitalized patients without localizing signs of infection.Methods150 patients with suspected HAI were conducted prospective study,diagnostic value of PCT and CRP in the detection of HAI were evaluated.ResultsThe sensitivity, specificity, positive predictive value and negative predictive value of PCT and CRP were (57.14% vs 76.19%）,（89.15% vs 48.06%）,（46.15% vs 19.28%）,and （92.74% vs 92.54%）,respectively. Positive likelihood ratio of PCT was higher than CRP （5.26 vs 1.46）. The area under the curve(AUC）was 0.80 (95% CI： 0.68-0.91) for PCT and 0.73 (95% CI： 0.63-0.82) for CRP;the optimal cutoff value was 7.49 ng/mL for PCT and 39.01 mg/L for CRP.ConclusionPCT and CRP are valuable for diagnosing HAI, the specificity and positive predictive value of PCT are higher than CRP.