ObjectiveTo investigate the application of quinolones, so as to promote the rational use of antimicrobial agents.Methods Four hospitals in Dongguan area were randomly selected, 1 085 prescriptions and related medical records of outpatients from April to May 2013 were analyzed retrospectively.ResultsA total of 6 kinds of quinolones were used, three most frequently used quinolones were levofloxacin（48.01%）, ciprofloxacin（28.52%） and ofloxacin（13.90%）; 85.53% of prescriptions were intravenous drip (928 cases, 654 were only intravenous drip,274 were intravenous drip plus oral administration), quinolones were commonly used in the treatment of urinary tract infection（358 cases，33.00%）, digestive system infection（305 cases，28.11%）, and lower respiratory tract infection（211 cases，19.45%）; 166 prescriptions were 2drug combination, 3drug and more combination use was not found; irrational combination drug use existed, including combination of oral administration of quinolones and H2 receptor blocking agents， H+ pump inhibitors, magnesium and aluminiumcontaining antiacids.ConclusionThe prescriptions of quinolones for outpatients in this area are basically rational, but the choice of indications, combination use, dosage form, and dosage administration need to be improved.