ObjectiveTo assess clinical efficacy and safety of linezolid in treating postoperative intracranial infection after neurosurgery operation, and provide clinical basis for the treatment of postoperative intracranial infection.MethodsFrom January 2011 to December 2012,clinical data of 51 neurosurgery patients receiving linezolid for treating postoperative intracranial infection were collected, changes in symptoms, temperature, cerebrospinal fluid (CSF) bacterial culture, as well as white blood cell (WBC) count, protein and glucose in CSF before and after therapy were compared, clinical efficacy and safety of linezolid in the treatment of postoperative intracranial infection were assessed based on the diagnostic criteria for intracranial infection.ResultsAfter linezolid treatment, 30 cases of postoperative intracranial infection were cured, and linezolid was effective in 12 cases, improved in 5 cases, and ineffective in 4 cases, total effective rate was 92.16%. Of 47 cases with effective therapy, the mean therapy day were 12.5 d (2-27 d）, 11 of whom isolated grampositive bacteria from CSF before therapy, and CSF culture were all negative after linezolid therapy. ConclusionLinezolid is effective for treating intracranial infection caused by Staphylococci, Enterococci and other grampositive bacteria which failed to response to vancomycin therapy.