ObjectiveTo investigate the risk factors for imipenemresistant Pseudomonas aeruginosa (IRPA) infections in Xi’an,  and provide reference for  the control of IRPA infections .Methods103 IRPA patients who were hospitalized at 4 hospitals in Xi’an between February and October 2013 were randomly selected(case group),103 imipenemsusceptible Pseudomonas aeruginosainfected patients during the same hospitalization period were as control group, risk factors for IRPA infection were analyzed.ResultsUnivariate analysis revealed that old age, length of hospital stay≥4 weeks, chronic pulmonary diseases, stay in intensive care unit, mechanical ventilation, use carbapenems (imipenem, meropenem) 2 weeks before the isolation of IRPA ,and early combination of  antimicrobial drugs were related risk factors for IRPA infection;Logistic multivariate analysis showed that length of hospital stay≥4 weeks（OR95%CI：1.44-139.73）, mechanical ventilation（OR95%CI：2.96-267.75）,and use carbapenems (imipenem, meropenem)2 weeks before the isolation of IRPA（OR95% CI：2.65-154.34）were independent risk factors for IRPA infection.ConclusionIRPA infection in patients in this area should be intervened to reduce risk factors for IRPA infection.