ObjectiveTo evaluate risk factors for multidrugresistant Acinetobacter baumannii (MDRAB) infection, so as to provide reference  for making preventive and control measures of MDRAB infection.MethodsClinical data of patients with Acinetobacter baumannii (A. baumannii ) infection in a hospital between April 2011 and  September 2012 were surveyed, distribution and specimen sources of A. baumannii  and MDRAB were analyzed, and risk factors of MDRAB were assessed.ResultsOf 236 isolates of A. baumannii, 74 (31.36%) were MDRAB . The isolation rate of MDRAB in intensive care unit and neurosurgery department was up to 60.00%（27/45）and 58.06%（18/31）respectively; MDRAB were mainly isolated from wound （45.45%）, respiratory tract （34.27%）, and urinary tract（17.65%）.Univariate analysis revealed that difference in length of hospital stay, use of serum albumin, fiberbronchoscopy, coma days, tracheotomy, use of ventilator, incisional drainage, urinary catheterization, use of carbapenems, and antimicrobial days in different groups were statistically different (P<0.05). Multivariate logistic regression analysis revealed that  tracheotomy（OR95%CI：1.152-7.187）, use of ventilator（OR95%CI：1.263-7.664）were independent risk factors for MDRAB infection. ConclusionTracheotomy and use of ventilator play an important role in the producing and spreading of MDRAB , management on drugresistant bacteria is important in reducing MDRAB infection.