国内糖尿病常见社区获得性感染及其危险因素的Meta分析
作者:
作者单位:

作者简介:

王笑歌

通讯作者:

中图分类号:

R587.1

基金项目:

国家十一五科技支撑项目(2007BAI24B004);辽宁省科技厅项目(20132253030);沈阳市科技局项目(F12-277-1-71)


Communityacquired infections and risk factors in patients with diabetes: A Metaanalysis
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 文章评论
    摘要:

    目的采用循证医学系统分析方法分析国内糖尿病患者合并社区获得性感染的种类及其危险因素。方法计算机检索中国学术期刊网全文数据库(CNKI)、万方数据库、维普数据库,汇总国内发表的有关糖尿病合并社区获得性感染及危险因素的研究,应用stata 11.0软件进行Meta分析。结果共纳入12篇文献。糖尿病患者社区获得性感染率为22.12%~55.86%,平均39.55%。常见感染(感染发生率)为呼吸系统感染(40.74%)、泌尿系统感染(27.35%)、结核(10.80%)、皮肤黏膜感染(9.19%)、肝胆系统感染(5.57%)。按照纳入文献危险因素进行分层分析,结果显示,合并慢性并发症、年龄、病程、血糖控制情况、性别、糖尿病类型和酮症酸中毒各亚组合并OR及OR95%CI分别为1.63(1.45,1.82)、1.30(1.19,1.42)、1.47(1.35,1.61)、0.68(0.61,0.76)、0.69(0.64,0.75)、1.37(1.13,1.66 )和0.87(0.62,1.23)。对各危险因素亚组发表偏倚和敏感性进行分析,结果显示,发表偏倚不明显,合并结果稳定性较好。结论国内糖尿病患者常见社区获得性感染依次为:呼吸系统感染、泌尿系统感染、结核、皮肤软组织感染等;女性、高龄、病程长、血糖控制不佳、有并发症均可导致糖尿病患者社区获得性感染的概率增加。

    Abstract:

    ObjectiveTo analyze the types and risk factors of communityacquired infections (CAI) in diabetic patients by system analysis method of evidencebased medicine. MethodsChina National  Knowledge Infrastructure (CNKI),  Wanfang database, VIP database were searched by computer,  domestic published researches on CAI and related risk factors in diabetic patients were aggregated, Metaanalysis was conducted by stata 11.0 software.ResultsA total of 12 literatures were included in the study . The average rate of CAI in diabetic patients was 39.55% (22.12%-55.86%). The major infections  were  respiratory system infection(40.74%), urinary tract infection(27.35%), tuberculosis(10.80%), skin and soft tissue infection(9.19%), and hepatobiliary system infection (5.57%). Stratified analysis on risk factors revealed that OR and OR95%CI  of chronic complication, age, disease course, glycemic control, gender, type of diabetes, subtype of ketoacidosis was 1.63( 1.45,1.82),1.30(1.19,1.42),1.47( 1.35,1.61), 0.68(0.61,0.76),0.69(0.64,0.75),1.37(1.13,1.66 ) and 0.87(0.62,1.23),respectively. There was no publication bias and combined results were stable. ConclusionThe main CAI in diabetic patients are respiratory system infection, urinary tract infection, tuberculosis, skin and soft tissue infection, and so on ;several factors, such as female, older age, longterm  disease course,  poor glycemic control, and complication, can contribute to the increase of CAI in diabetic patients.

    参考文献
    相似文献
引用本文

赵广丹,赵明静,李方治,等.国内糖尿病常见社区获得性感染及其危险因素的Meta分析[J]. 中国感染控制杂志,2014,13(10):577-583. DOI:10.3969/j. issn.1671-9638.2014.10.001.
ZHAO Guangdan, ZHAO Mingjing, LI Fangzhi, et al. Communityacquired infections and risk factors in patients with diabetes: A Metaanalysis[J]. Chin J Infect Control, 2014,13(10):577-583. DOI:10.3969/j. issn.1671-9638.2014.10.001.

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2014-04-08
  • 最后修改日期:2014-06-12
  • 录用日期:
  • 在线发布日期: 2014-10-30
  • 出版日期: