ObjectiveTo explore risk factors for surgical site infection(SSI) in orthopaedic surgery, and propose the intervention measures.Methods1 082 patients who received orthopaedic surgery in a hospital from January 2012 to December 2013 were monitored, SSI were surveyed by healthcareassociated infection control professionals  based on  medical records reviewing, onsite examination of surgical incision and postdischarged following up call. ResultsOf 1 082 patients, 8(0.74%) developed SSI. Univariate analysis revealed that SSI were related to  patients’ age, associated diabetes mellitus, emergency operation, incision numbers, types of incisions, duration of operation,and  implant (P<0.05); Logistic regression analysis revealed that independent risk factors for SSI were age, diabetes mellitus, emergency operation, incision numbers, incision types, and duration of operation (P<0.05). ConclusionMultiple factors contribute to SSI in orthopaedic surgery. It is necessary to take comprehensive prevention measures to reduce the incidence of SSI.