ObjectiveTo understand the impact of methicillinresistant Staphylococcus aureus (MRSA) bloodstream infection on the length of hospital stay, hospital mortality, and poor prognosis of patients.  Methods357 patients with Staphylococcus aureus (S.aureus) bacteremia  in a hospital between January 1,2009 and December 31,2013 were surveyed and analyzed retrospectively.   ResultsOf 357 patients, 91 were infected with MRSA and 266 with methicillinsusceptible S.aureus (MSSA).  The length of hospital stay was statistically different between MRSA and MSSA group(29 d vs 23 d, P＜0.01）; before infection, length of hospital stay of MRSA group was longer than MSSA group（P＜0.01）; after infection, length of hospital stay was not statistically different between two groups（17 d vs 16.5 d, P=0.92）. Mortality of MRSA group and MSSA group was not statistically different（13.19％ vs 9.02％, χ2=1.28，P=0.26）. The incidence of poor prognosis of MRSA group was higher than  MSSA group(29.67％ vs 16.92％, χ2=6.85，P=0.01）. Multivariate analysis results showed that  MRSA infection was independent risk factor for poor prognosis (P＜0.01). ConclusionMRSA infection doesn’t contribute to the prolongation of hospital stay, but MRSA bloodstream infection is a risk factor for poor prognosis of patients.