重症肺炎患儿血小板参数与凝血指标的探讨
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黄彩芝

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R725.6

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Evaluation on platelet parameters and coagulation indicators in children with severe pneumonia
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    摘要:

    目的探讨重症肺炎患儿血小板参数和凝血指标的变化及其临床价值。方法选取重症肺炎患儿97例,根据是否合并呼吸系统以外的其他系统疾病,将患儿分为重症肺炎 Ⅰ 组和重症肺炎 Ⅱ 组,同时,选取30例健康儿童作为对照组,比较3组儿童血小板参数[血小板计数(PLT)、平均血小板体积(MPV)]和凝血指标[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、抗凝血酶Ⅲ(ATⅢ)和D二聚体(DD)]情况。结果3组间PLT、MPV、DD和ATⅢ活性比较,差异均有统计学意义(均P<0.05)。重症肺炎Ⅰ组PLT、MPV、DD分别为(454.00±157.00) ×109/L、(9.66±1.24) fL、(0.47±0.37) mg/L,均高于对照组[分别为(300.00±63.00) ×109/L、(8.90±0.37) fL、(0.27±0.06) mg/L];ATⅢ活性低于对照组[(79.91±20.34)% vs(107.03±8.11)%],差异均有统计学意义(均P<0.05)。重症肺炎Ⅱ组ATⅢ和PLT水平分别为(66.11±11.12)%、(279.00±185.00)×109/L 低于重症肺炎 Ⅰ 组,MPV和DD水平分别为(10.37±1.51)fL、(0.70±0.46) mg/L,均高于重症肺炎 Ⅰ 组,差异均有统计学意义(均P<0.05)。结论重症肺炎患儿存在明显的凝血功能紊乱,PLT、MPV、ATⅢ和DD水平变化与患儿的病情严重程度有关。

    Abstract:

    ObjectiveTo study the changes and clinical value of platelet(PLT) parameters and coagulation indicators in children with severe pneumonia. Methods97 children were divided into severe pneumonia group Ⅰ and severe pneumonia group Ⅱ according to whether children were associated with other diseases besides severe pneumonia, and 30 healthy children were in control group. The levels of PLT count, mean platelet volume(MPV), prothrombin time(PT), activated partial thromboplastin time(APTT), fibrinogen(FIB), antithrombinⅢ(ATⅢ), and Ddimer(DD) among three groups were compared. ResultsThe differences of PLT,MPV,DD and ATⅢ activities were all significant  among  three groups (all P<0.05). PLT, MPV and DD levels in group Ⅰwere all significantly higher than those of control group ([454.00±157.00]×109/L vs [300.00±63.00]×109/L ; [9.66±1.24]fL vs [8.90±0.37] fL; [0.47±0.37] mg/L vs [0.27±0.06] mg/L, respectively); ATⅢ activity in groupⅠ was lower than control group([79.91±20.34]% vs[107.03±8.11]%) (both P<0.05). ATⅢ activity and  PLT level in group Ⅱwas (66.11±11.12)% and (279.00±185.00)×109/L  respectively, which were both significantly lower than  group Ⅰ, MPV and DD level was (10.37±1.51)fL and (0.70±0.46) mg/L respectively, which were both higher than groupⅠ (both P<0.05). ConclusionThere is obvious coagulation dysfunction in children with severe pneumonia. The changes in PLT,MPV, ATⅢ and DD levels are associated with the severity of pneumonia.

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引用本文

黄彩芝,莫丽亚,邓永超,等.重症肺炎患儿血小板参数与凝血指标的探讨[J]. 中国感染控制杂志,2015,14(2):98-100. DOI:10.3969/j. issn.1671-9638.2015.02.007.
HUANG Caizhi, MO Liya, DENG Yongchao, et al. Evaluation on platelet parameters and coagulation indicators in children with severe pneumonia[J]. Chin J Infect Control, 2015,14(2):98-100. DOI:10.3969/j. issn.1671-9638.2015.02.007.

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  • 收稿日期:2014-06-15
  • 最后修改日期:2014-08-22
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  • 在线发布日期: 2015-02-28
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