ObjectiveTo evaluate the features of disinfectantresistant genes in methicillinresistant Staphylococcus aureus (MRSA) in China through Metaanalysis.MethodsLiteratures about features of disinfectantresistant genes in MRSA were searched from  China National Knowledge Infrastructure（CNKI）, Wanfang Med Online, PubMed, and Excerpta  Medica Database (EMbase) through  computerized   retrieval system, literatures were selected according to standard inclusion and exclusion criteria, Metaanalysis was performed using R3.1.1 software and RevMan 5.3 software.ResultsA total of 42 literatures were included, involving disinfectantresistant genes of 2 671 strains of MRSA from 16 provinces (municipalities) in China. The overall detection rate of qacA/B, qacC, qacJ and norA was 28.03%(95%CI: 20.03%-36.48%), 8.94%(95%CI: 1.27%-22.49%), 17.74%(95%CI: 2.25%-43.39%), and 17.90%(95%CI: 0.00%-76.38%) respectively. The detection rates of qacEΔ1, qacG, and qacH were 0.00%. The overall detection rate of qacA/B of the southern and northern China areas was 27.12% (95%CI: 19.03%-36.06%) and 30.14% (95%CI: 13.11%-50.63%) respectively, there was no statistical difference between two areas (Z=0.59, P>0.05). The overall detection rate of qacA/B in the eastern, central and western economic region was 29.95% (95%CI: 21.85%-38.73%), 22.65% (95%CI: 10.08%-38.47%), and 26.94% (95%CI: 3.78%-60.95%) respectively, there was no statistical difference among these regions (P>0.05). The detection rates of qacA/B in hospitalacquired (HA)MRSA and communityacquired (CA)MRSA were not statistically different (OR and 95%CI=0.69［0.14-3.31］, P=0.64). The detection rate of qacA/B in MRSA was  higher than those in methicillinsensitive Staphylococcus aureus (MSSA) (OR and 95%CI=4.99［3.53-7.06］，P＜0.01）. ConclusionDetection rate of disinfectantresistant genes in MRSA is high in China, which is common and serious , monitoring on disinfectantresistant genes  should be enhanced, disinfectants should be used rationally.