ObjectiveTo investigate the occurrence of central venous catheterrelated bloodstream infection(CRBSI) in mass severe burn patients, evaluate related risk factors for infection, and effectiveness of prevention and control measures. MethodsIn August 2014, 9 cases of severe burn patients were rescued in a hospital, all patients received CVC, infection prevention and control intervention measures were performed during the whole process of catheterization. ResultsAll  patients received 30 episodes of CVC，total CVCdays were 227 days， bacterial culture for threecavity catheters of femoral veins in 2 patients were positive, incidence of CRBSI was 8.81‰；1 patient was isolated Enterococcus faecium,1 isolated both Acinetobacter baumannii and  Stenotrophomonas maltophilia. 2 CRBSI patients received femoral vein catheterization, catheterization site was trauma surface, duration of catheterization were both ≥7 days, both used threecavity catheters, and third degree burns  were ≥60%, both patients were cured after timely removal of catheters and receiving of antimicrobial agents.  ConclusionCVC is helpful for long term, safe and effective fluid infusion, but it can cause CRBSI; infection prevention and control intervention for patients receiving CVC  during the whole process of catheterization can reduce the occurrence of CRBSI.