ObjectiveTo explore the change trend and antimicrobial resistance of pathogens causing infection in extensive burn patients, and provide reference for clinical prevention and treatment.MethodsSpecimens from 9 extensive burn patients who were admitted to a hospital at the same time were performed pathogenic culture and antimicrobial susceptibility testing, change trend and antimicrobial susceptibility of pathogens were observed.ResultsThe main specimen was wound secretion, accounting for 93.81%. The major pathogens causing infection were Acinetobacter baumannii (44.85%), Staphylococcus aureus (32.47%), Pseudomonas aeruginosa (12.37%), and Klebsiella pneumoniae (5.15%). With the prolongation of hospital stay, pathogens changed from one kind to multiple strains, and from susceptibility to resistance,multidrug resistance,and extensive drug resistance. ConclusionIt is difficult to avoid infection in burn patients, timely realizing the changes of pathogens causing infection and antimicrobial resistance play an important role in the control of infection.