ObjectiveTo investigate the management of prevention and control of catheterrelated bloodstream infection (CRBSI) in intensive care units (ICUs) of tertiary hospitals in a city, and explore stategies. MethodsData about CRBSI prevention and control as well as quality management were collected and surveyed by selfdeveloped questionnaires.  ResultsOf ICUs in 8 hospitals, the incidence of CRBSI was 4.81‰, case infection rate was 5.02‰. 6（75.00%） hospitals had standard operating instruction for the prevention and control of CRBSI, 2 (25.00%) hospitals had maintenance record on central venous catheter, and 2(25.00%) hospitals implemented maximum sterile barrier and catheterization combination strategy, none hospital adopted antiinfective dressing and chlorhexidine bathing.ConclusionThere are many problems in the standard operating instruction and implementation of measures for the prevention and control of CRBSI in ICUs of tertiary hospitals in this city, which needs to be improved.