ObjectiveTo evaluate the effect of plandocheckact (PDCA)  cycle method in improving disinfection efficacy of object surface in intensive care unit ( ICU).MethodsOn the basis of management of healthcareassociated infection (HAI) and prevention of multidrugresistant organisms, disinfection efficacy of object surface in an ICU was intervened, data about surface object specimens taken before, during, and after intervention, HAI in patients, as well as detection of MDROs  were collected.ResultsThe total qualified rate of specimens taken before, during, and after intervention  was 58.24%, 76.74%, and 88.71%，respectively, there was an increased tendency,the difference was significant （χ2=17.41，P=0.009）; the incidence of HAI was 3.72%,2.42%, and 1.78%，respectively, there was a decreased tendency（χ2=6.03，P=0.039）， case infection rate was 4.36%,2.75%, and 2.37% respectively，there was a decreased tendency（χ2=7.24，P=0.046）；detection rate of MDROs was 34.03%,27.45%, and 14.05%，respectively, there was a decreased tendency （χ2=33.84，P=0.007），the percentage of patients who were detected MDROs and HAI caused by MDROs showed a decreased tendency（χ2=6.14, 6.02，both P<0.05）.ConclusionThe implementation of PDCA cycle can effectively improve disinfectant efficacy of ICU object surface, and reduce the incidence of MDRO HAI.